منابع مشابه
TAp63: The fountain of youth
The mechanisms controlling organismal aging have yet to be clearly defined. In our recent paper [1], we revealed thatTAp63, the p53 family member, is a critical gene in preventing organismal aging by controlling the maintenance of dermal and epidermal precursor and stem cells critical for wound healing and hair growth. In the absence of TAp63, dermal stem cells (skin-derived precursors or SKPs)...
متن کاملIn search of the fountain of youth.
In Greek mythology, Klotho spins the thread of life. In human biology, Klotho protein was so named when researchers discovered that mutations that interrupt its normal function result in a shorter thread of life that is attributable to accelerated aging.1 From its initial discovery, the kidney and its role in phosphate and calcium handling have been at the epicenter of the Klotho story. a, b, a...
متن کاملBone marrow: a fountain of vascular youth?
Just a few years ago, the rules of blood vessel formation seemed simple. Endothelial cells emerged from the blood islands of the embryo to form primitive tubes, the precursors of the vasculature. Smooth muscle cells, recruited locally from various germ layers, invested the endothelial tubes, forming the sandwich structure of mature arteries and veins. Mechanical or metabolic injury supposedly s...
متن کاملApical meristems: the plant's fountain of youth.
During postembryonic development, all organs of a plant are ultimately derived from a few pluripotent stem cells found in specialized structures called apical meristems. Here we discuss our current knowledge about the regulation of plant stem cells and their environments with main emphasis on the shoot apical meristem of Arabidopsis thaliana. Recent studies suggest that stem cells are localized...
متن کاملBile acids in the fountain of youth
lucky enough to drink water from the fountain of youth could retard its aging process, as the legend tells. Most likely, water was not the only element in the legendary fountain. What else could be found in there? We may never know! But scientists could come across their own anti-aging ingredients using model organisms and collections of chemical compounds, as the Titorenko's lab reports in thi...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2017
ISSN: 0148-396X,1524-4040
DOI: 10.1093/neuros/nyx235